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Dick Powell starred in the Richard Diamond, Private Detective radio series as a wisecracking former police officer turned private detective. Episodes typically open with a client visiting or calling cash-strapped Diamond's office and agreeing to his fee of $100 a day plus expenses, or Diamond taking on a case at the behest of his friend and former partner, Lt. Walter Levinson. Diamond often suffers a blow to the head in his sleuthing pursuits. Most episodes end with Diamond at the piano, singing a standard, popular song, or showtune from Powell's repertoire to Helen Asher (his girlfriend) in her penthouse at 975 Park Avenue.

The series is one of the earliest nationwide programs to feature Jack Webb.

Friday had joined the police shortly before World War II; Ben Romero was his first partner. After Friday was discharged from the U.S. Army, he returned to the police and the pair eventually reunited in the Detective Division, prior to the events of the series. Joe Friday is a fictional character created and portrayed by Jack Webb as the lead for his series Dragnet. Friday is a detective in the Los Angeles Police Department. The character first appeared on June 3, 1949, in the premiere of the NBC radio drama that launched the series. Webb played the character on radio and later television from 1949 to 1959 and again from 1967 to 1970, also appearing as Friday in a 1954 theatrical release and a 1966 made-for-TV film.

Like the Falcon film series, the radio plots mixed danger, romance and comedy in equal parts. Each show began with a telephone ringing and Michael Waring, the Falcon, answering the phone. Speaking with a woman whose voice was never heard, Waring would explain that he had an urgent situation in which he had to deal with criminals. This led into the standard opening, followed by the week's tale of adventure. Often, incompetent police were unable to solve the mysteries without his help.

Yours Truly, Johnny Dollar is a radio drama that aired on CBS Radio from February 18, 1949 to September 30, 1962. The first several seasons imagined protagonist Johnny Dollar as a private investigator drama, with Charles Russell, Edmond O'Brien and John Lund portraying Dollar in succession over the years. In 1955 after a yearlong hiatus, the series came back in its best-known incarnation with Bob Bailey starring in "the transcribed adventures of the man with the action-packed expense account – America's fabulous freelance insurance investigator." There were 809 episodes (plus two not-for-broadcast auditions) in the 13-year run, and more than 710 still exist today. Jim Cox's book American Radio Networks: A History cites "886 total performances" which includes repeat performances.

The Adventures of Sam Spade, Detective was a radio series based loosely on the private detective character Sam Spade, created by writer Dashiell Hammett for The Maltese Falcon. The show ran for 13 episodes on ABC in 1946, for 157 episodes on CBS in 1946–1949, and finally for 75 episodes on NBC in 1949–1951. The series starred Howard Duff (and later, Steve Dunne) as Sam Spade and Lurene Tuttle as his secretary Effie, and took a considerably more tongue-in-cheek approach to the character than the novel or movie. The announcer was Dick Joy.[1] Spade’s greetings and farewells to Effie (“Me, sweetheart” and “Goodnight, sweetheart” respectively) are a recurring motif on the show. Keeping with this, period standard ”Goodnight Sweetheart” was used as the closing theme of each episode.

Night Beat, sometimes spelled Nightbeat, is an NBC radio drama series that aired February 6, 1950 – September 25, 1952, sponsored by Pabst Blue Ribbon Beer and Wheaties. Frank Lovejoy starred as Randy Stone, a reporter who covered the night beat for the Chicago Star, encountering criminals, eccentrics, and troubled souls. Listeners were invited to join Stone as he "searches through the city for the strange stories waiting for him in the darkness." Most episodes leaned towards suspense, crime and thriller themes, but Night Beat also featured occasional humorous or sentimental stories. Each episode ended with Stone at his desk as he finished typing a news story based on his latest exploits, and shouting for the copy boy to deliver his story to an editor.

The Adventures of Father Brown is an American radio crime drama that aired on the Mutual Broadcasting System, adapted from G. K. Chesterton's stories of Father Brown. It debuted on June 10, 1945, and ended on July 29, 1945. Each episode began with commission of a crime, after which Father Brown's help was sought either by the police or by someone affected by the crime. Father brown solved each crime by thinking as the criminal would have thought. He said, "When I've reached the point of committing the crime myself, then I know who the criminal is." He worked with Detective Flambeau more than any other policeman. The series shifted the setting to "the contemporary American scene"

Barrie Craig, Confidential Investigator was a detective drama heard on NBC Radio from October 3, 1951 to June 30, 1955. Detective Barrie Craig (William Gargan) worked alone from his Madison Avenue office. Unlike his contemporaries Sam Spade and Philip Marlowe, Craig had a laid-back personality, somewhat cutting against the popular hard-boiled detective stereotype. Others in the cast included Ralph Bell, Elspeth Eric, Parker Fennelly, Santos Ortega, Arnold Moss, Parley Baer, Virginia Gregg and Betty Lou Gerson. Don Pardo was the announcer. The program was broadcast on Wednesdays at 10 p.m. Eastern Time. Writers included John Roeburt.

The Adventures of Philip Marlowe was a radio series featuring Raymond Chandler's private eye, Philip Marlowe. Robert C. Reinehr and Jon D. Swartz, in their book, The A to Z of Old Time Radio, noted that the program differed from most others in its genre: "It was a more hard-boiled program than many of the other private detective shows of the time, containing few quips or quaint characters."

The New Adventures of Nero Wolfe is a 1950–51 American radio drama series starring Sydney Greenstreet as Rex Stout's fictional armchair detective Nero Wolfe. Based on Stout's principal characters but not his stories, the series aired October 20, 1950 – April 27, 1951, on NBC. It is regarded as the series that is most responsible for popularizing Nero Wolfe on radio.

The Shadow was a popular American radio show that aired from 1930 to 1954, featuring Lamont Cranston, a wealthy young man who used a hypnotic power to "cloud men's minds" and become invisible as he fought crime. The character originated as the mysterious, sinister narrator on the 1930 radio show Detective Story Hour before becoming the star of his own series, famously voiced by Orson Welles in the late 1930s. The show's iconic opening line was, "Who knows what evil lurks in the hearts of men? The Shadow knows!"

Pursuit was an American radio crime drama on the CBS network from 1949 to 1952, featuring the investigations of Inspector Peter Black of Scotland Yard. The series was produced by Elliott Lewis and featured actors like Ted de Corsia, John Dehner, and Ben Wright as Inspector Black.

Pete Kelly's Blues was an American crime-musical radio drama which aired over NBC as an unsponsored summer replacement series on Wednesday nights at 8 pm (et) from July 4 through September 19, 1951. The series starred Jack Webb as Pete Kelly and was created by writer Richard L. Breen, who had previously worked with Webb on Pat Novak for Hire; James Moser and Jo Eisinger wrote most of the other scripts. It ran concurrently with Webb's best known radio series, Dragnet.

The Saint was a radio adventure program in the United States that featured a character ("a swashbuckling, devil-may-care Robin Hood type who, in his attempt to help people, remained just one step ahead of the police and crooks—both of whom he combatted") created by author Leslie Charteris. As the program's introduction said, The Saint (the alias of Simon Templar), was "known to millions from books, magazines, and motion pictures." Several versions of the program appeared on different networks.

Box 13 is a syndicated radio drama about the escapades of newspaperman-turned-mystery novelist Dan Holiday, played by film star Alan Ladd. Created by Ladd's company, Mayfair Productions, Box 13 aired in different cities over different dates and times. It first aired in several United States radio markets in October 1947.

Dangerous Assignment was an NBC Radio drama starring Brian Donlevy broadcast in the US 1949–1953, a syndicated television series distributed in the US 1951–52 (also starring Brian Donlevy), and an Australian radio series broadcast in 1954-56 as remakes of the original American radio scripts.

Gang Busters is an American dramatic radio program heralded as "the only national program that brings you authentic police case histories." It premiered on January 15, 1936 and was broadcast for more 21 years through November 27, 1957.

The Whistler is an American radio mystery drama which ran from May 16, 1942, until September 22, 1955, on the west-coast regional CBS radio network. The show was also broadcast in Chicago and over Armed Forces Radio. On the West Coast of the United States, it was sponsored by the Signal Oil Company: "That whistle is your signal for the Signal Oil program, The Whistler." There were also two short-lived attempts to form east-coast broadcast spurs: July 3 to September 25, 1946, sponsored by the Campbell Soup Company; and March 26, 1947, to September 29, 1948, sponsored by Household Finance. The program was also adapted into a film noir series by Columbia Pictures in 1944.

Pat Novak, for Hire is an old-time radio detective drama series which aired from 1946 to 1947 as a West Coast regional program (produced at KGO in San Francisco) and in 1949 as a nationwide program for ABC.

Mr. and Mrs. North are fictional American amateur detectives. Created by Frances and Richard Lockridge, the couple was featured in a series of 26 Mr. and Mrs. North novels, a Broadway play, a motion picture and several radio and television series.